How Chromofungin May Help Crohn’s Disease

Chromofungin, also known as chromogranin A-derived peptide, is a protein fragment that has been studied for its potential anti-inflammatory properties. While research on Chromofungin specifically for Crohn’s disease is limited, its general mechanism of action could provide some insights into its potential benefits:

  1. Anti-Inflammatory Effects: Chromofungin has shown anti-inflammatory properties in various studies. Since Crohn’s disease is characterized by chronic inflammation of the gastrointestinal tract, Chromofungin could help reduce this inflammation, potentially alleviating some symptoms.
  2. Immune System Modulation: Crohn’s disease involves an overactive immune response. Chromofungin might modulate the immune system, helping to balance the immune response and reduce the pathological inflammation associated with Crohn’s disease.
  3. Gut Barrier Protection: Maintaining the integrity of the gut barrier is crucial in Crohn’s disease. Chromofungin could potentially help in strengthening the gut barrier, preventing the translocation of bacteria and toxins that exacerbate the disease.
  4. Antimicrobial Properties: Some research suggests that Chromofungin has antimicrobial effects. This could be beneficial in Crohn’s disease, where an imbalance in gut microbiota (dysbiosis) is often observed.

While these potential benefits are promising, more specific research is needed to confirm the efficacy and safety of Chromofungin in the treatment of Crohn’s disease. It’s important for patients to consult with their healthcare provider before considering new treatments.

Exploring BPC-157: A Potential New Avenue for Crohn’s Disease Treatment?

In the continuous quest for effective treatments for chronic conditions, a new contender has emerged in the arena of regenerative medicine: BPC-157. This synthetic peptide, known for its healing properties, particularly in the gastrointestinal tract, has sparked interest in the medical community, especially concerning Crohn’s disease, a challenging and often debilitating inflammatory bowel disease.

What is BPC-157?

BPC-157, a Body Protection Compound, is a sequence of amino acids synthetically produced based on a protective protein found in the human stomach. Over the years, it has gained attention for its remarkable regenerative properties, especially in animal and in vitro studies. Its potential roles include accelerating wound healing, promoting tissue repair, and reducing inflammation, making it a point of interest for researchers looking at gastrointestinal diseases.

BPC-157 and Crohn’s Disease

Crohn’s disease is characterized by chronic inflammation of the gastrointestinal tract, leading to symptoms like abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition. The healing and anti-inflammatory properties of BPC-157 could theoretically offer relief and recovery for those suffering from Crohn’s.

Current Research

Most of the studies on BPC-157 have been limited to animal models or conducted in vitro. These studies have shown promising results, such as reduced inflammation and facilitated healing of intestinal lesions, which are common in Crohn’s disease. However, the leap from animal models to human applications is significant, and there’s a scarcity of clinical trials on humans to validate these findings.

Safety and Regulations

One of the critical aspects of considering BPC-157 as a treatment option is its regulatory status. Currently, BPC-157 is not approved by major regulatory bodies like the FDA for human use. This lack of approval raises questions about its safety and efficacy for human use, particularly long-term.

Consulting Healthcare Professionals

For individuals with Crohn’s disease, any new treatment, including BPC-157, should be discussed with a healthcare professional. They can provide guidance considering the current research, individual health status, and potential risks associated with unregulated treatments.

Conclusion

While BPC-157 presents an intriguing possibility for aiding in Crohn’s disease treatment, the road to its acceptance in standard medical practice is long and requires more rigorous clinical trials. For now, it remains a subject of research and curiosity rather than a recommended treatment. As with any emerging therapy, staying informed and consulting with healthcare providers is crucial for those seeking new avenues to manage their health conditions.

Disclaimer

This blog post is for informational purposes only and does not constitute medical advice. Always consult with a healthcare professional for medical advice and treatment.

Sources

  1. Sikiric, Predrag, et al. “Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract.” Curr Pharm Des. 2011;17(16):1612-32. doi: 10.2174/138161211796196954. PubMed.
  2. Sikiric, Predrag, et al. “Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia). Full and distended stomach, and vascular response.” Inflammopharmacology. 2006 Dec;14(5-6):214-21. doi: 10.1007/s10787-006-1531-7. PubMed.
  3. Vuksic, T., et al. “Stable gastric pentadecapeptide BPC 157 heals ileoileal anastomosis in the rat.” Surg Today. 2007;37(9):768-77. doi: 10.1007/s00595-006-3498-9. PubMed.
  4. Sikiric, Predrag, et al. “Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157.” Curr Pharm Des. 2013;19(1):76-83. doi: 10.2174/13816128130111. PubMed.
  5. Cesarec, Vedran, et al. “Pentadecapeptide BPC 157 and the esophagocutaneous fistula healing therapy.” Eur J Pharmacol. 2013 Feb 15;701(1-3):203-12. doi: 10.1016/j.ejphar.2012.11.055. PubMed.
  6. Vitaic, S., et al. “Nonsteroidal anti-inflammatory drugs-induced failure of lower esophageal and pyloric sphincter and counteraction of sphincters failure with stable gastric pentadecapeptide BPC 157 in rats.” J Physiol Pharmacol. 2017 Apr;68(2):265-272. PubMed.
  7. Staresinic, M., et al. “BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing.” Curr Pharm Des. 2018;24(18):1972-1989. doi: 10.2174/1381612824666180712110447. PubMed.
  8. Sikiric, Predrag, et al. “Stable Gastric Pentadecapeptide BPC 157 May Recover Brain-Gut Axis and Gut-Brain Axis Function.” Pharmaceuticals (Basel). 2023 Apr 30;16(5):676. doi: 10.3390/ph16050676. PubMed.

The link between Crohn’s disease and mental health

The relationship between Crohn’s disease and mental health issues such as depression, anxiety, and OCD is multifaceted. Firstly, it’s established that living with Crohn’s disease can increase a person’s risk of developing depression or other mental health conditions. However, there is no evidence suggesting that depression can cause Crohn’s disease. Depression and anxiety are notably common among people who have Crohn’s disease. The most prevalent psychiatric disorders in inflammatory bowel disease, which includes Crohn’s disease, are depression and anxiety. There is also some evidence suggesting an increased occurrence of other disorders like bipolar disorder in these patients.

The connection between Crohn’s disease and mental health issues is partly explained by the brain-gut link through the vagus nerve, where signals run in both directions. This connection is significant in understanding the susceptibility to developing mental disorders in people with inflammatory bowel disease.

Regarding the role of serotonin, it has been found that serotonin levels are elevated in patients with Crohn’s disease. This neurotransmitter, predominantly produced by gut enterochromaffin cells, is crucial in gastrointestinal functions, including motility, sensitivity, secretion, and the inflammatory response. It has been suggested that a high level of serotonin could be partly responsible for the inflammation in chronic gastrointestinal diseases like Crohn’s and may even trigger flare-ups. The gut microbiota dysbiosis and dysfunction of the serotonergic system contribute to inflammatory bowel disease, including Crohn’s disease, indicating that gut bacteria can induce serotonin. Serotonin has a strong impact on the development of intestinal inflammation, altering the body’s ability to recycle damaged compounds within cells, a process known as autophagy.

Sources

  1. “Inflammatory bowel disease is a group of chronic medical conditions comprising Crohn’s disease and ulcerative colitis that involves increased frequency of mental disorders.” PubMed Central, National Institutes of Health, www.ncbi.nlm.nih.gov/pmc/articles/PMC6993663/.
  2. “Living with Crohn’s disease can increase a person’s risk of developing depression or other mental health conditions.” Medical News Today, www.medicalnewstoday.com/articles/the-link-between-crohns-and-depression.
  3. “Depression and anxiety are common among people who have Crohn’s disease.” MyCrohnsAndColitisTeam, www.mycrohnsandcolitisteam.com/resources/depression-and-anxiety-with-crohns-disease.
  4. “The brain-gut link through the vagus nerve is significant in understanding the susceptibility to developing mental disorders in people with inflammatory bowel disease.” WebMD, www.webmd.com/ibd-crohns-disease/crohns-disease/features/crohns-mental-health.
  5. “Serotonin levels have been found to be elevated in patients with Crohn’s disease.” Chromatography Today, www.chromatographytoday.com/news/hplc-uhplc/31/breaking-news/can-serotonin-levels-be-used-to-diagnose-crohns-disease-chromatography-explores/53349.
  6. “The gut microbiota dysbiosis and dysfunction of the serotonergic system contribute to inflammatory bowel disease, including Crohn’s disease.” Nature, www.nature.com/articles/s41385-020-00363-4.
  7. “Serotonin has a strong impact on the development of intestinal inflammation.” Academic OUP, academic.oup.com/femspd/article/78/10/ftaa067.

87% of Crohn’s Patients Can Eat Some Form of Bread

We asked 134 people with Crohn’s disease if they could eat bread and offered three possible answers to our survey.

47% said they could eat all types of bread.

40% said they could eat certain kinds of bread. Examples of that are white breads, or anything that isn’t whole grain, etc.

The remaining 13% said they can’t eat any breads.

This means 87% of Crohn’s patients can eat some type of bread.

87% of Crohn’s Patients Claim Lean Meats Cause Less Pain

Magazines and health professionals have suggested limiting red meat in your diet for a long time. It’s also been discussed often in the IBD space that red meat can be tough to digest and should be avoid. However, I noticed people say steak doesn’t bother their digestion. So I had to run a survey.

82 of the 93 respondents said chicken and turkey caused less pain than red meats did. That equates to a whopping 87% – one of our least divided surveys ever.

Of the 13% that said the meats digested similar, one said the rarer the meat, the easier it was to digest. My guess is those that find them similar, they are in remission or closer to it.

Remember, even in remission, it’s important to stick with safe foods. Even thought your gut is stronger now, abusing it can return you to your old days and it will. It happens all the time. People with IBD for over 25 years end up in the ER and when questioned on their diet, they say “what diet?”

3 Studies Testing Cannabis as Treatment for Crohn’s Disease

Prior to 2011, there was pretty much no research on the results of consuming cannabis to lower the effects of Crohn’s disease. Since then, studies have shed light on the substance.

Study 1

In a study published in The Israel Medical Association Journal, they studied 30 patients with active Crohn’s disease.

“The average Harvey Bradshaw index improved from 14 ± 6.7 to 7 ± 4.7,” the study reported. The Harvey Bradshaw index is one of the indexes used to measure Crohn’s disease activity.

Patients consumed one to three cannabis sativa joints per day, which each contained around 0.5 mg of THC. The CBD values were not reported or noted, although the study noted both cannabinoids have been known to have profound anti-inflammatory effects prior to the study.

Image result for 1 gram joint
Comparing joint sizes. Source: Nevada Says No

0.5 mg in the study seems low or incorrect. Let’s say you roll a 1 gram joint, and the vendor claims 15% THC, which is typical – not overly high and certainly not low. Let’s factor in the fact that the number is probably exaggerated a bit, so we’ll say 10% of absorbable THC.

1000 mg joint * 0.10 THC = 100 mg of THC per joint

100 mg is 200x the amount reported in the study, but luckily we have other studies.

Source: Treatment of Crohn’s disease with cannabis: an observational study. (PMID:21910367)

Study 2

In the next study, patients also consumed cannabis sativa. This was placebo-controlled. A decreased Crohn’s Disease Activity Score of >100 was observed in 10 of 11 subjects in the cannabis group (90%; from 330 ± 105 to 152 ± 109) and 4 of 10 in the placebo group (40%; from 373 ± 94 to 306 ± 143; P = .028).

I think it’s worth noting that 40% of people on placebo thought the effects were beneficial, as CDAI is based on a survey. Although not necessarily proper to do so, we could subtract 40% provided from the placebo group from the cannabis group (90%) and conclude it’s actually 50% effective.

In this study, patients took the cannabis via cigarette form, twice daily, with each joint containing 115 mg of Δ9-tetrahydrocannabinol (THC). That’s a 1 gram joint with a medium level of THC content.

Study 3

In another study that focused in CBD, researchers found that after offering low dosages of CBD (10 mg, twice daily) to Crohn’s disease patients, CBD was safe to consume but did not offer any beneficial effects. This was concluded to be either because CBD has no effect on Crohn’s disease activity or because the dosage was too low.

Bonus Note

“Its benefit may be simply derived from pain relief and not from improvement in inflammation” said one study.

Conclusions

  • Sativa is generally used in medicinal purposes over indica
  • Smoking 2-3 joints per day has proven beneficial in many cases
  • Smoking is not the only form that works – vaporizing via a bong and digesting via edibles is also effective
  • Cannabis is known to have a placebo effect and may not always help as much as patients believe
  • Researchers have yet not found benefits of CBD

Books on Cannabis and Crohn’s


70% of Crohn’s Disease Patients Find Dairy Gives Them Pain

Recently I asked members of a Crohn’s & Ulcerative Colitis group whether or not dairy gave them abdominal pain. Including my vote, of the 109 respondents, 76 said that dairy did indeed give them abdominal pain, which is 70% of the respondents.

“Dairy products have been perceived as having the potential to cause adverse effects in individuals with Crohn’s disease (CD) and are often avoided.” said one study. Specifically, “dairy products with a high fat content were most frequently reported to worsen perceived CD symptoms.”

Top 5 Shake Supplements for Crohn’s Disease

Doctors often recommend a 2000 calorie diet to maintain an overall healthy body – that includes a healthy weight, organs acting as they should, etc. However, that number is different based on each person, so first you should calculate your own calorie intake by watching this video.

Calories are made of up one of the 3 macronutrients: protein, carbohydrates and fats. You need a balance of all 3. The ratio recommended normally for those who don’t participate in heavy physical activity is:

  • 10–35% from protein
  • 45–65% from carbs
  • 20–35% from fats

The problem with most pre-made shakes like Ensure is they are expensive, and not very mobile. They also include a ton of sugar. When you’re going to drink purely shakes for multiple days to get through a flare, you will need a lot of shakes. Each Ensure is 220 calories, meaning you’ll need at least 9 per day. However, you can make your own and only have 3 sizeable shakes – one for each meal.

In this article, I will show you the ingredients you need to make a proper shake that fulfills your daily nutrition goals.

To mix these, you should add water and/or an alternative milk source. My favorite is oat milk. For flavor, you can add a banana. Then blend it.

Image result for oat milk earths own
Image result for fruits and veggies blender

Protein

For protein, my two favorite sources are from egg whites or yellow split peas. Eggs as a whole are fine when eating solid foods but if you eat more than half a dozen a day (which you need to to hit macro goals), you’re daily cholesterol will be something you need to watch.

Less Naked Pea – Vanilla Pea Protein

Now Sports Nutrition – Egg White Protein

Carbohydrates

For carbohydrates, sweet potatoes are my favorite source of complex carbs. For simple carbs, dextrose powder is a great option. To refresh your memory, complex and simple carbs are both fine but often complex carbs are favored because the energy they provide is extended throughout your day whereas simple carbs give you an instant energy boost, like candy does to a kid. One is not necessarily more healthy than the other per se. You can use either or both based on your needs.

Also note: you can easily add in fruits to your shakes when blending to add tasty carbs.

Now Sports Nutrition – Dextrose Powder

True Nutrition – Sweet Potato Powder

Fats

Fats give the most dense calories and are probably the nutrient with the most misunderstanding from the general public. I talk about fats more in other articles and on YouTube. Unsaturated fats are good, but some saturated fats are also good if it’s extracted, such as MCT. One of the best sources of fat is just that, MCT Oil, which often found in the health food aisle of your local grocery store.

The majority of saturated fat is long chain triglycerides which is bad. MCT is medium chain triglycerides and they are really only in coconut. However, in coconut oil, they are only a small percentage of the total saturated fats which is why coconut oil as a whole is not recommended. MCT also have health benefits associated with them. You can add the oil in it’s original form, oil, to your shakes or add the powder below. Both are fine.

Giant Sports International – MCT Oil Powder

Bonus: Total Meal Replacement

One of the strongest men in the world, Brian Shaw, uses this meal replacement in addition to some massive meals to help him stay healthy and strong. The only difference? He eats about 10x the amount you’ll be eating. Point being – this stuff works and it’s effective in staying healthy, full of energy and strong.

Image result for brian shaw pulling
Brian Shaw, one of the world’s strongest men

Redcon1 – MRE Real Whole Food – Chicken Protein, Salmon Protein, Oatmeal Powder & Dehydrated Sweet Potato

Choosing a Proper Protein Source with Crohn’s Disease

Most Crohn’s patients suffer from some form of malabsorption. This means we must choose protein sources that are easy to digest – which is measured based on bioavailability. Bioavailability is the proportion of the nutrient that is digested, absorbed and metabolized through normal pathways.

Leading in bioavailability, whey protein isolate tops the chart with an index over 100. Although, since most Crohn’s patients have intolerances to dairy due to lack of proper enzymes that means eggs are the most reliable and most efficient protein source for Crohn’s sufferers.

For vegan options, the only protein with proper absorption comparable to chicken, egg and other traditional sources is pea protein isolate.